Building biology must not stop at the gate. Apartments and houses usually do not exist by themselves but are part of villages, towns, and cities. This alone is not only a major intervention into nature but also has a major impact on human well-being. If the basic rules of ecosocial regional planning are applied, it is possible to create life-sustaining communities that live in harmony with healthy natural surroundings. However, if they are ignored, mental and physical health disorders may increase and the effects of environmental destruction may spin completely out of control in the long run. What should a culture-based and sustainable urban planning paradigm look like from a building biology perspective?